| 存储条件 |
|---|
| Product Name | MMP11 [SN74-08] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Matrix Metalloproteinase 11 antibody Matrix metalloproteinase-11 antibody MMP-11 antibody Mmp11 antibody MMP11_HUMAN antibody SL 3 antibody SL-3 antibody SL3 antibody ST3 antibody STMY3 antibody Stromelysin 3 antibody Stromelysin III antibody Stromelysin-3 antibody |
| Product description | The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHC |
| WB:1:1,000 ICC:1:500-1:1,000 IHC:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | Matrix Metalloproteinase 11 antibody Matrix metalloproteinase-11 antibody MMP-11 antibody Mmp11 antibody MMP11_HUMAN antibody SL 3 antibody SL-3 antibody SL3 antibody ST3 antibody STMY3 antibody Stromelysin 3 antibody Stromelysin III antibody Stromelysin-3 antibody |
|---|---|
| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Secreted. |
Application
Fig1: Western blot analysis of MMP11 on mouse spleen lysates using anti-MMP11 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining MMP11 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining MMP11 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: ICC staining MMP11 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-MMP11 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-MMP11 antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-MMP11 antibody. Counter stained with hematoxylin.| Positive Control | SW480, MCF-7, A549, human breast carcinoma tissue, human spleen tissue, mouse spleen tissue. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:500-1:1,000 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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