| 存储条件 |
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| Product Name | APBA2 [G11-G5] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Adapter protein X11beta antibody Amyloid beta A4 precursor protein-binding family A member 2 antibody APBA2 antibody APBA2_HUMAN antibody D15S1518E antibody HsT16821 antibody LIN 10 antibody MGC:14091 antibody MGC99508 antibody Mint 2 antibody Mint-2 antibody MINT2 antibody Neuron-specific X11L protein antibody Neuronal Munc18-1-interacting protein 2 antibody Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody X11 beta antibody X11 like protein antibody X11l antibody |
| Product description | The β-Amyloid precursor protein (β-APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The β-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the β-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β-APP and slowing β-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β-APP. Multiple splice varitents of X11 have been identified, including X11α (also designated Mint 1), X11β (Mint 2) and X11γ (Mint 3). |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:250~1:1000 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Adapter protein X11beta antibody Amyloid beta A4 precursor protein-binding family A member 2 antibody APBA2 antibody APBA2_HUMAN antibody D15S1518E antibody HsT16821 antibody LIN 10 antibody MGC:14091 antibody MGC99508 antibody Mint 2 antibody Mint-2 antibody MINT2 antibody Neuron-specific X11L protein antibody Neuronal Munc18-1-interacting protein 2 antibody Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody X11 beta antibody X11 like protein antibody X11l antibody |
|---|---|
| Molecular Weight(MW) | 83 kDa |
| Cellular Localization | Plasma membrane,synaptic vesicle. |
| SwissProt ID | Q99767 |
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Application
Fig1: Western blot analysis of APBA2 on human APBA2 recombinant protein using anti-APBA2 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of APBA2 on HEK293 (1) and APBA2-hIgGFc transfected HEK293 (2) cell lysate using anti-APBA2 antibody at 1/1,000 dilution.
Application
Fig3: Flow cytometric analysis of Hela cells with APBA2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human APBA2 recombinant protein, APBA2-hIgGFc transfected HEK293 cell lysate, Hela. |
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| Application Notes | WB:1:250~1:1000 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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