1810024J13Rik antibody ABP125 antibody ABP130 antibody AU042160 antibody DKFZp686N07171 antibody HSPC275 antibody HSPC334 antibody KIAA0905 antibody MGC90305 antibody MGC93320 antibody Protein transport protein Sec31A antibody SEC31 homolog A (S. cerevisiae) antibody SEC31 like 1 antibody SEC31 like protein 1 antibody SEC31 related protein A antibody SEC31L1 antibody VAP1 antibody Web1 like protein antibody Yeast Sec31p homolog antibody
Product description
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Sec31A, also known as ABP125, ABP130 or SEC31L1, is a 1,220 amino acid protein that contains seven WD repeats and localizes to the cytoplasm and to cytoplasmic vesicles, as well as to the membrane of the endoplasmic reticulum (ER). Expressed ubiquitously at high levels, Sec31A functions as a component of the COP II (coat protein II) complex and, working in tandem with other proteins, promotes the formation of ER transport vesicles and aids in the selection of cargo molecules. Chromosomal aberrations that involve the Sec31A gene are associated with inflammatory myofibroblastic tumors (IMTs), suggesting a role for Sec31A in carcinogenesis. Multiple isoforms of Sec31A exist due to alternative splicing events.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WBIHC
WB:1:500-1:2,000 IHC:1:50-1:200
Species Reactivity
Human
Concentration
2mg/ml
Purification
Unpurified
Target Information
Alternative Names
1810024J13Rik antibody ABP125 antibody ABP130 antibody AU042160 antibody DKFZp686N07171 antibody HSPC275 antibody HSPC334 antibody KIAA0905 antibody MGC90305 antibody MGC93320 antibody Protein transport protein Sec31A antibody SEC31 homolog A (S. cerevisiae) antibody SEC31 like 1 antibody SEC31 like protein 1 antibody SEC31 related protein A antibody SEC31L1 antibody VAP1 antibody Web1 like protein antibody Yeast Sec31p homolog antibody
Fig1: Western blot analysis of SEC31A on human SEC31A recombinant protein using anti-SEC31A antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of SEC31A on HEK293 (1) and SEC31A-hIgGFc transfected HEK293 (2) cell lysate using anti-SEC31A antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human ?ovarian cancer tissue using anti-SEC31A antibody. Counter stained with hematoxylin.
Positive Control
Human SEC31A recombinant protein, SEC31A-hIgGFc transfected HEK293 cell lysate, human ?ovarian cancer tissue.
Application Notes
WB:1:500-1:2,000 IHC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
