E3 ubiquitin protein ligase NEDD4 like protein antibody E3 ubiquitin-protein ligase NEDD4-like antibody KIAA0439 antibody NED4L_HUMAN antibody NEDD4 2 antibody NEDD4 2c antibody Nedd4-2 antibody NEDD4-2a antibody NEDD4.2 antibody NEDD4b antibody NEDD4L antibody NEDD4La antibody NEDD4Lb antibody NEDD4Lc antibody NEDD4Ld antibody NEDD4Le antibody NEDD4Lf antibody NEDD4Lg antibody NEDD4Lh antibody NEDL3 antibody Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody Neural precursor cell expressed, developmentally down regulated 4 like antibody RSP5 antibody Ubiquitin protein ligase Rsp5 antibody
Product description
NEDD4-L (neural precursor cell expressed, developmentally down-regulated 4-like), also known as RSP5, NEDD4-2 or NEDL3, is a 975 amino acid protein that localizes to the cytoplasm and contains four WW domains, one HECT domain and one C2 domain. Expressed ubiquitously with highest expression in pancreas, prostate and kidney, NEDD4-L functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Through its ability to ubiquitinate and induce the proteasome-dependent degradation of proteins such as Smad2 and TGFβ RII, NEDD4-L is thought to inhibit the TGFβ signaling pathway, thereby regulating the signaling pathways that control cell growth and differentiation. NEDD4-L is expressed as eight isoforms due to alternative splicing events.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIP
WB:1:1,000-1:5,000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
E3 ubiquitin protein ligase NEDD4 like protein antibody E3 ubiquitin-protein ligase NEDD4-like antibody KIAA0439 antibody NED4L_HUMAN antibody NEDD4 2 antibody NEDD4 2c antibody Nedd4-2 antibody NEDD4-2a antibody NEDD4.2 antibody NEDD4b antibody NEDD4L antibody NEDD4La antibody NEDD4Lb antibody NEDD4Lc antibody NEDD4Ld antibody NEDD4Le antibody NEDD4Lf antibody NEDD4Lg antibody NEDD4Lh antibody NEDL3 antibody Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody Neural precursor cell expressed developmentally down regulated 4 like antibody RSP5 antibody Ubiquitin protein ligase Rsp5 antibody
