| 存储条件 |
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| Product Name | alpha 1 Catenin [SC0619] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Alpha E-catenin antibody Cadherin associated protein 102kDa antibody Cadherin associated protein antibody Cadherin-associated protein antibody CAP 102 antibody CAP102 antibody Catenin (cadherin associated protein) alpha 1 102kDa antibody Catenin (cadherin associated protein), alpha 1, 102kDa antibody Catenin alpha 1 antibody Catenin alpha-1 antibody CTNA1_HUMAN antibody CTNNA 1 antibody Ctnna1 antibody FLJ36832 antibody FLJ52416 antibody NY REN 13 antigen antibody OTTHUMP00000224141 antibody OTTHUMP00000224147 antibody Renal carcinoma antigen NY REN 13 antibody Renal carcinoma antigen NY-REN-13 antibody |
| Product description | α E-catenin (also designated α-catenin; cadherin-associated protein, α1, 102 kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHCIPFC |
| WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | Alpha E-catenin antibody Cadherin associated protein 102kDa antibody Cadherin associated protein antibody Cadherin-associated protein antibody CAP 102 antibody CAP102 antibody Catenin (cadherin associated protein) alpha 1 102kDa antibody Catenin (cadherin associated protein) alpha 1 102kDa antibody Catenin alpha 1 antibody Catenin alpha-1 antibody CTNA1_HUMAN antibody CTNNA 1 antibody Ctnna1 antibody FLJ36832 antibody FLJ52416 antibody NY REN 13 antigen antibody OTTHUMP00000224141 antibody OTTHUMP00000224147 antibody Renal carcinoma antigen NY REN 13 antibody Renal carcinoma antigen NY-REN-13 antibody |
|---|---|
| Molecular Weight(MW) | 100 kDa |
| Cellular Localization | Cytoplasm, Cell junction, Cell membrane. |
Application
Fig1: Western blot analysis of alpha 1 Catenin on different lysates using anti-alpha 1 Catenin antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: HepG2 Lane 3: A431
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of Hela cells with alpha 1 Catenin antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.| Positive Control | A431, Hela, HepG2, mouse colon tissue, mouse prostate tissue, mouse uterus tissue. |
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| Application Notes | WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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