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| Product Name | CHRNA7 [G1-F10] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | 7nAChR antibody a7 nicotinic acetylcholine receptor antibody acetylcholine receptor, neuronal nicotinic, alpha-7 subunit antibody ACHA7_HUMAN antibody AChR antibody Acra7 antibody alpha 7 neuronal nicotinic acetylcholine receptor antibody alpha-7 nicotinic cholinergic receptor subunit antibody alpha7 antibody cholinergic receptor, neuronal nicotinic, alpha polypeptide 7 antibody cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody cholinergic receptor, nicotinic, alpha 7 antibody cholinergic receptor, nicotinic, alpha polypeptide 7 antibody CHRNA7 antibody CHRNA7-2 antibody NACHRA7 antibody neuronal acetylcholine receptor protein, alpha-7 chain antibody Neuronal acetylcholine receptor subunit alpha-7 antibody |
| Product description | Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRα7, also known as NACHRA7, CHRNA7-2 or CHRNA7, is a 502 amino acid multi-pass membrane protein existing as a homopentamer and interacts with RIC-3, a nicotinic acetylcholine receptor (nAChR)-associated protein. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 7nAChR antibody a7 nicotinic acetylcholine receptor antibody acetylcholine receptor neuronal nicotinic alpha-7 subunit antibody ACHA7_HUMAN antibody AChR antibody Acra7 antibody alpha 7 neuronal nicotinic acetylcholine receptor antibody alpha-7 nicotinic cholinergic receptor subunit antibody alpha7 antibody cholinergic receptor neuronal nicotinic alpha polypeptide 7 antibody cholinergic receptor nicotinic alpha 7 (neuronal) antibody cholinergic receptor nicotinic alpha 7 antibody cholinergic receptor nicotinic alpha polypeptide 7 antibody CHRNA7 antibody CHRNA7-2 antibody NACHRA7 antibody neuronal acetylcholine receptor protein alpha-7 chain antibody Neuronal acetylcholine receptor subunit alpha-7 antibody |
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| Molecular Weight(MW) | 56 kDa |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane. Cell membrane |
| SwissProt ID | P36544 |
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Application
Fig1: Western blot analysis of CHRNA7 on human CHRNA7 recombinant protein using anti-CHRNA7 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of CHRNA7 on HEK293 (1) and CHRNA7-hIgGFc transfected HEK293 (2) cell lysate using anti-CHRNA7 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human bladder cancer tissue using anti-CHRNA7 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-CHRNA7 antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of SH-SY5Y cells with CHRNA7 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human CHRNA7 recombinant protein, CHRNA7-hIgGFc transfected HEK293 cell lysate, human bladder cancer tissue, human rectum cancer tissue, SH-SY5Y. |
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| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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