| 存储条件 |
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| Product Name | WAS [E10-4B] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Eczema thrombocytopenia antibody IMD2 antibody SCNX antibody THC antibody THC1 antibody Thrombocytopenia 1 (X linked) antibody U42471 antibody Was antibody WASp antibody WASP_HUMAN antibody Wiskott Aldrich syndrome (eczema thrombocytopenia) antibody Wiskott Aldrich syndrome antibody Wiskott Aldrich syndrome protein antibody Wiskott-Aldrich syndrome protein antibody |
| Product description | The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Eczema thrombocytopenia antibody IMD2 antibody SCNX antibody THC antibody THC1 antibody Thrombocytopenia 1 (X linked) antibody U42471 antibody Was antibody WASp antibody WASP_HUMAN antibody Wiskott Aldrich syndrome (eczema thrombocytopenia) antibody Wiskott Aldrich syndrome antibody Wiskott Aldrich syndrome protein antibody Wiskott-Aldrich syndrome protein antibody |
|---|---|
| Molecular Weight(MW) | 53 kDa |
| Cellular Localization | Cytoplasm, cytoskeleton |
| SwissProt ID | P42768 |
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Application
Fig1: Western blot analysis of WASp on human WASp recombinant protein using anti-WASp antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of WASp on HEK293 (1) and WASp-hIgGFc transfected HEK293 (2) cell lysate using anti-WASp antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-WASp antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-WASp antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of Hela cells with WASp antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human WASp recombinant protein, WASp-hIgGFc transfected HEK293 cell lysate, human ovarian cancer tissue, human colon cancer tissue, Hela. |
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| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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