| 存储条件 |
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| Product Name | Acetyl CoA Carboxylase 1(ACC1) [ST53-08] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACAC antibody ACACA antibody ACACA_HUMAN antibody ACACB antibody ACC alpha antibody ACC antibody ACC beta antibody ACC-alpha antibody ACC1 antibody ACC2 antibody ACCA antibody ACCB antibody Acetyl CoA carboxylase 1 antibody Acetyl CoA carboxylase 2 antibody Acetyl CoA carboxylase alpha antibody Acetyl CoA carboxylase beta antibody Acetyl Coenzyme A carboxylase alpha antibody Acetyl Coenzyme A carboxylase beta antibody Biotin carboxylase antibody COA1 antibody COA2 antibody HACC275 antibody OTTHUMP00000164069 antibody OTTHUMP00000164070 antibody OTTHUMP00000164076 antibody OTTHUMP00000240532 antibody |
| Product description | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | ACAC antibody ACACA antibody ACACA_HUMAN antibody ACACB antibody ACC alpha antibody ACC antibody ACC beta antibody ACC-alpha antibody ACC1 antibody ACC2 antibody ACCA antibody ACCB antibody Acetyl CoA carboxylase 1 antibody Acetyl CoA carboxylase 2 antibody Acetyl CoA carboxylase alpha antibody Acetyl CoA carboxylase beta antibody Acetyl Coenzyme A carboxylase alpha antibody Acetyl Coenzyme A carboxylase beta antibody Biotin carboxylase antibody COA1 antibody COA2 antibody HACC275 antibody OTTHUMP00000164069 antibody OTTHUMP00000164070 antibody OTTHUMP00000164076 antibody OTTHUMP00000240532 antibody |
|---|---|
| Molecular Weight(MW) | 265 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of Acetyl CoA Carboxylase 1 on mouse kidney lysates using anti-Acetyl CoA Carboxylase 1 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Acetyl CoA Carboxylase 1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Acetyl CoA Carboxylase 1 antibody. Counter stained with hematoxylin.| Positive Control | Human kidney tissue, mouse placenta tissue, mouse kidney lysates. |
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| Application Notes | WB:1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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