| 存储条件 |
|---|
| Product Name | ZO2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | C9DUPq21.11 antibody DFNA51 antibody DUP9q21.11 antibody Friedreich ataxia region gene X104 (tight junction protein ZO-2) antibody MGC26306 antibody PFIC4 antibody Tight junction protein 2 antibody Tight junction protein ZO 2 antibody Tight junction protein ZO-2 antibody TJP2 antibody X104 antibody ZO 2 antibody ZO-2 antibody ZO2 antibody ZO2_HUMAN antibody Zona occludens 2 antibody Zona occludens protein 2 antibody Zonula occludens protein 2 antibody |
| Product description | Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton. ZO-1 and -2 are required for tight junction formation and function. In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators. |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICC |
| WB:1:1000-1:2000 ICC:1:100-1:200 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | C9DUPq21.11 antibody DFNA51 antibody DUP9q21.11 antibody Friedreich ataxia region gene X104 (tight junction protein ZO-2) antibody MGC26306 antibody PFIC4 antibody Tight junction protein 2 antibody Tight junction protein ZO 2 antibody Tight junction protein ZO-2 antibody TJP2 antibody X104 antibody ZO 2 antibody ZO-2 antibody ZO2 antibody ZO2_HUMAN antibody Zona occludens 2 antibody Zona occludens protein 2 antibody Zonula occludens protein 2 antibody |
|---|---|
| Molecular Weight(MW) | 150 kDa |
| Cellular Localization | Cell membrane |
| SwissProt ID | Q9UDY2 |
|---|
Application
Fig1: Western blot analysis on cell lysates using anti-ZO2 rabbit polyclonal antibodies.
Application
Fig2: ICC staining ZO2 in A431 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | A431, F9, 293 |
|---|---|
| Application Notes | WB:1:1000-1:2000 ICC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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