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CHFR

产品编号 : OM638773

英文名称 : CHFR

中文名称 : 抗体

品牌 : OmnimAbs

包装规格	交货周期	质量标准	目录价	会员专享价	数量
50ul	现货2-3天	原装正品	￥2880	登录后可见	- +
100ul	现货2-3天	原装正品	￥3960	登录后可见	- +
20ul	现货2-3天	原装正品	￥3960	登录后可见	- +

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基础信息

存储条件

产品详情

Product Profile

Product Name	CHFR
Antibody Type	Primary Antibodies
Antigen Alias	Checkpoint with forkhead and ring finger domains antibody Checkpoint with forkhead and RING finger domains protein antibody Chfr antibody CHFR_HUMAN antibody E3 ubiquitin protein ligase CHFR antibody E3 ubiquitin-protein ligase CHFR antibody EC 6.3.2. antibody FLJ10796 antibody FLJ33629 antibody RING finger protein 196 antibody RNF 116 antibody RNF 196 antibody RNF116 antibody RNF196 antibody Ubiquitin ligase protein antibody
Product description	E3 ubiquitin-protein ligase (CHFR) that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. CHFR is probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Marked reduction of CHFR expression was detected in primary tumors and decreased CHFR expression was linked to promoter hypermethylation. Restoration of CHFR expression by treatment with the microtubule stress agent nocodazole and the methyltransferase inhibitor 5-aza-2'-deoxycytidine has been reported.
Immunogen	peptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBICC
	WB:1:500-1:1,000 ICC:1:200
Species Reactivity	Human
Concentration	1mg/ml

Target Information

Alternative Names	Checkpoint with forkhead and ring finger domains antibody Checkpoint with forkhead and RING finger domains protein antibody Chfr antibody CHFR_HUMAN antibody E3 ubiquitin protein ligase CHFR antibody E3 ubiquitin-protein ligase CHFR antibody EC 6.3.2. antibody FLJ10796 antibody FLJ33629 antibody RING finger protein 196 antibody RNF 116 antibody RNF 196 antibody RNF116 antibody RNF196 antibody Ubiquitin ligase protein antibody
Molecular Weight(MW)	~73kDa
Cellular Localization	Nucleus

Database Links

SwissProt ID	Q96EP1

Application

Fig1: Western blot analysis on Hela cell lysates using anti-CHFR rabbit polyclonal antibodies.

Application

Fig2: ICC staining CHFR in A431 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).

Positive Control	Hela, A431
Application Notes	WB:1:500-1:1,000 ICC:1:200

Additional Information

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

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