Anti-Mannose Receptor antibody [15-2]

• 产品名称

  Anti-Mannose Receptor抗体[15-2]
  参阅全部 Mannose Receptor 一抗

• 描述

  小鼠单克隆抗体[15-2] to Mannose Receptor

• 宿主

  Mouse

• 经测试应用

  适用于: IHC-Frmore details
  不适用于: IHC-P

• 种属反应性

  与反应: Human
  

• 免疫原

  Purified human mannose receptor from human placental tissue.

• 表位

  Stains extracellular domain of Mannose Receptor.

• 阳性对照

• Macrophages IHC: liver endothelial cells and Kupffer cells, spermatids, spermatozoa

• 常规说明

  The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells.

  
  

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• 形式

  Liquid

• 存放说明

  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

• 存储溶液

  Constituents: PBS, 0.1% BSA

• 浓度

• 50 µg 浓度为 0.1 mg/ml

• 纯度

  Protein G purified

• 纯化说明

  0.2 µm filtered antibody solution

• Primary antibody说明

  The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells.

• 克隆

  单克隆

• 克隆编号

  15-2

• 骨髓瘤

  unknown

• 同种型

  IgG1

• 轻链类型

  unknown

The Abpromise guarantee

Abpromise™承诺保证使用ab8918于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用说明

Is unsuitable for IHC-P.

• 数据库链接

• Entrez Gene: 4360 Human

• Omim: 153618 Human

• SwissProt: P22897 Human

• Unigene: 75182 Human

• 别名

• CD 206 antibody

• CD206 antibody

• CD206 antigen antibody

• CLEC13D antibody

• CLEC13DL antibody

• Macrophage mannose receptor 1 antibody

• Macrophage mannose receptor 1 like protein 1 antibody

• Macrophage mannose receptor antibody

• Mannose receptor C type 1 antibody

• Mannose receptor C type 1 like 1 antibody

• MMR antibody

• MRC 1 antibody

• MRC1 antibody

• MRC1_HUMAN antibody

• MRC1L1 antibody

• OTTHUMP00000045206 antibody

• bA541I19.1 antibody

• C type lectin domain family 13 member D antibody

• C-type lectin domain family 13 member D antibody

• 

  Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)

  Frozen sections of human tonsil. ab8918 was used in a dilution of 1/25 and shows staining of endothelia of lymph vessels.

• 

  Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)This image is a courtesy of Pat Bell

  ab8918 staining Mannose Receptor in human mammary gland tissue section by Immunohistochemistry (Frozen sections). Tissue samples were fixed with 70% Ethanol and blocking for 10 minutes at RT was performed. The sample was incubated with primary antibody (1/10) for 1 hour. A HRP-conjugated mouse polyclonal to mouse IgG was used undiluted as secondary antibody.

  See Abreview

• 

  Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)This image is courtesy of an anonymous Abreview

  Immunohistochemical analysis of murine uterus tissue sections, staining Mannose Receptor with ab8918.
  
  Tissue was fixed with paraformaldehyde and blocked with 3% BSA for 30 minutes at room temperature. Samples were incubated with primary antibody (1/40 in 1% BSA) for 1.5 hours. An undiluted HRP-conjugated rabbit anti-mouse polyclonal IgG was used as the secondary antibody.

  See Abreview

• 

  Immunohistochemistry (Frozen sections) - Anti-Mannose Receptor antibody [15-2] (ab8918)This image is courtesy of an Abreview submitted by Aimée-Lys Rusesabagina

  ab8918 staining Mannose Receptor in human endometriosis tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with acetone and blocked with 10% serum for 1 hour at 22°C. Samples were incubated with primary antibody (1/10 in PBS + 1% NGS) for 16 hours at 4°C. An undiluted HRP-conjugated goat anti-mouse IgG polyclonal was used as the secondary antibody.

  See Abreview