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| Product Name | AP2 gamma [A5-A11] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Activating enhancer binding protein 2 gamma antibody Activating enhancer-binding protein 2 gamma antibody AP2-gamma antibody AP2C_HUMAN antibody AP2g antibody AP2gamma antibody ERF 1 antibody ERF1 antibody Estrogen receptor factor 1 antibody hAP 2g antibody hAP2g antibody TFAP 2C antibody TFAP 2G antibody Tfap2c antibody TFAP2G antibody Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma) antibody Transcription factor AP 2 gamma antibody Transcription factor AP-2 gamma antibody Transcription factor ERF 1 antibody Transcription factor ERF-1 antibody Transcription factor ERF1 antibody |
| Product description | AP-2 transcription factor family members include AP-2α, AP-2β and AP-2γ, which specifically bind to the DNA consensus sequence CCCCAGGC and initiate transcription of selected genes. AP-2, also known as ERF-1, plays a role in regulating estrogen receptor expression. AP-2β, a splice variant of AP-2α, inhibits AP-2 activity. Besides subscribing to the AP-2 complex, AP-2α, AP-2β and AP-2γ proteins compose the OB2-1 transcription factor complex. OB2-1 specifically upregulates expression of the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2α may play an important role in the development of ectodermal-derived tissues. Deleterious mutations involving the AP-2α gene are linked to microphthalmia, corneal clouding and other anterior eye chamber defects. The ubiquitously expressed AP-4 transcription factor specifically binds to the DNA consensus sequence 5′-CAGCTG-3′. AP-4 interacts with promoters for immunoglobulin-κ gene families and simian virus 40. AP-4 may enhance the transcription of the human Huntington's disease gene. AP-4 is a helix-loop-helix protein that contains two distinctive leucine repeat elements. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | Activating enhancer binding protein 2 gamma antibody Activating enhancer-binding protein 2 gamma antibody AP2-gamma antibody AP2C_HUMAN antibody AP2g antibody AP2gamma antibody ERF 1 antibody ERF1 antibody Estrogen receptor factor 1 antibody hAP 2g antibody hAP2g antibody TFAP 2C antibody TFAP 2G antibody Tfap2c antibody TFAP2G antibody Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma) antibody Transcription factor AP 2 gamma antibody Transcription factor AP-2 gamma antibody Transcription factor ERF 1 antibody Transcription factor ERF-1 antibody Transcription factor ERF1 antibody |
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| Molecular Weight(MW) | 49 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | Q92754 |
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Application
Fig1: Western blot analysis of AP2 gamma on human AP2 gamma recombinant protein using anti- AP2 gamma antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of AP2 gamma on HEK293 (1) and AP2 gamma -hIgGFc transfected HEK293 (2) cell lysate using anti- AP2 gamma antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of AP2 gamma on SK-Br-3 cell lysate using anti- AP2 gamma antibody at 1/1,000 dilution.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue using anti- AP2 gamma antibody. Counter stained with hematoxylin.| Positive Control | Human AP2 gamma recombinant protein, AP2 gamma -hIgGFc transfected HEK293 cell lysate, SK-Br-3, human esophageal cancer tissue. |
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| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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