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| Product Name | Junctional Adhesion Molecule 1 [SC60-07] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD 321 antibody CD321 antibody CD321 antigen antibody ESTM33 antibody F11 receptor antibody F11R antibody JAM 1 antibody JAM A antibody JAM antibody JAM-1 antibody JAM-A antibody JAM1 antibody JAM1_HUMAN antibody JAMA antibody JCAM antibody Jcam1 antibody Junction adhesion molecule 1 antibody Junction adhesion molecule, mouse, homolog of antibody Junctional adhesion molecule 1 antibody Junctional adhesion molecule A antibody KAT antibody Ly106 antibody PAM 1 antibody PAM-1 antibody PAM1 antibody Platelet adhesion molecule 1 antibody Platelet adhesion molecule antibody Platelet F11 receptor antibody PRO301 antibody UNQ264 antibody |
| Product description | Junctional adhesion molecule (JAM) is a member of the immunoglobulin superfamily expressed in tight junctions of epithelial cells and endothelial cells. It is implicated in transendothelial migration of leukocytes. JAM is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets and platelets. The JAM family consists of JAM-A, JAM-B and JAM-C, alternatively designated JAM-1, JAM-2 and JAM-3, respectively. JAM-A localizes with F-Actin at the cell-cell contacts and at the membrane ruffles. It is involved in cell to cell adhesion through homophilic interactions and plays a role in the organization of tight junctions and modulation of leukocyte extravasation. JAM-B interacts with discrete subsets of PBLs, suggesting that it may play a role in lymphocyte trafficking. JAM-B and JAM-C proteins are binding partners; JAM-C may be a functional JAM-B receptor. Specifically, JAM-B adheres to T cells through heterotypic interactions with JAM-C. The JAM-B/JAM-C interaction my play a role in T, NK and dendritic cellular inflammation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | CD 321 antibody CD321 antibody CD321 antigen antibody ESTM33 antibody F11 receptor antibody F11R antibody JAM 1 antibody JAM A antibody JAM antibody JAM-1 antibody JAM-A antibody JAM1 antibody JAM1_HUMAN antibody JAMA antibody JCAM antibody Jcam1 antibody Junction adhesion molecule 1 antibody Junction adhesion molecule mouse homolog of antibody Junctional adhesion molecule 1 antibody Junctional adhesion molecule A antibody KAT antibody Ly106 antibody PAM 1 antibody PAM-1 antibody PAM1 antibody Platelet adhesion molecule 1 antibody Platelet adhesion molecule antibody Platelet F11 receptor antibody PRO301 antibody UNQ264 antibody |
|---|---|
| Molecular Weight(MW) | 33 kDa |
| Cellular Localization | Cell junction, Cell membrane. |
Application
Fig1: Western blot analysis of JAM-1 on different lysates using anti-JAM-1 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Human liver
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-JAM-1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-JAM-1 antibody. Counter stained with hematoxylin.| Positive Control | Hela, HepG2, human liver tissue, mouse liver tissue, mouse brain tissue. |
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| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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