| 存储条件 |
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| Product Name | BTRC [D8-C5] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Beta transducin repeat containing E3 ubiquitin protein ligase antibody beta TrCP1 antibody beta-transducin repeat containing antibody BETA-TRCP antibody betaTrCP antibody btrC antibody bTrCP antibody bTrCP1 antibody E3RSIkappaB antibody F box and WD repeat protein 1B antibody F box and WD repeats protein beta TrCP antibody F-box and WD repeats protein beta-TrCP antibody F-box/WD repeat protein 1A antibody F-box/WD repeat-containing protein 1A antibody FBW1A antibody FBW1A_HUMAN antibody FBXW1 antibody FBXW1A antibody FWD1 antibody HOS antibody mKIAA4123 antibody pIkappaBalpha-E3 receptor subunit antibody Slimb antibody |
| Product description | b-tranducin repeats containing protein (b-TrCP), also designated E3RSIkB or FWD1, and HOS (homologous to Slimb) are F-box proteins that function as substrate recognition subunits of ubiquitin ligases. HOS and b-TrCP differ in their amino-terminal regions, but exhibit high homology within the F-box and WD40 repeat-containing regions. b-TrCP mediates ubiquitin/proteasome-dependent degradation of CD4 and ubiquitination of various proteins including IkB and b-catenin. HOS has also been shown to regulate the degradation of IkB and b-catenin in a similar manner. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Beta transducin repeat containing E3 ubiquitin protein ligase antibody beta TrCP1 antibody beta-transducin repeat containing antibody BETA-TRCP antibody betaTrCP antibody btrC antibody bTrCP antibody bTrCP1 antibody E3RSIkappaB antibody F box and WD repeat protein 1B antibody F box and WD repeats protein beta TrCP antibody F-box and WD repeats protein beta-TrCP antibody F-box/WD repeat protein 1A antibody F-box/WD repeat-containing protein 1A antibody FBW1A antibody FBW1A_HUMAN antibody FBXW1 antibody FBXW1A antibody FWD1 antibody HOS antibody mKIAA4123 antibody pIkappaBalpha-E3 receptor subunit antibody Slimb antibody |
|---|---|
| Molecular Weight(MW) | 69 kDa |
| Cellular Localization | Cytoplasm. Nucleus |
| SwissProt ID | Q9Y297 |
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Application
Fig1: Western blot analysis of BTRC on human BTRC recombinant protein using anti-BTRC antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of BTRC on HEK293 (1) and BTRC-hIgGFc transfected HEK293 (2) cell lysate using anti-BTRC antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of BTRC on different cell lysate using anti-BTRC antibody at 1/1,000 dilution. Positive control： Line1: Ramos Line2: MCF-7 Line3: K562
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue using anti-BTRC antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-BTRC antibody. Counter stained with hematoxylin.
Application
Fig6: Flow cytometric analysis of Hela cells with BTRC antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human BTRC recombinant protein, BTRC-hIgGFc transfected HEK293 cell lysate, Ramos, MCF-7, K562 cell lysates, human esophageal cancer tissue, human rectum cancer tissue, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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