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| Product Name | MuRF1 [B8-E1] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | E3 ubiquitin-protein ligase TRIM63 antibody FLJ32380 antibody IRF antibody Iris RING finger protein antibody MURF 1 antibody MURF-1 antibody MuRF1 antibody MURF2 antibody Muscle specific ring finger protein 1 antibody Muscle specific ring finger protein 2 antibody Muscle-specific RING finger protein 1 antibody OTTHUMP00000008701 antibody RING finger protein 28 antibody RNF 28 antibody RNF28 antibody SMRZ antibody Striated muscle RING zinc finger protein antibody TRI63_HUMAN antibody TRIM 63 antibody Trim63 antibody Tripartite motif containing 63 antibody tripartite motif containing 63, E3 ubiquitin protein ligase antibody Tripartite motif containing protein 63 antibody Tripartite motif-containing protein 63 antibody Ubiquitin ligase TRIM63 antibody |
| Product description | Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICCIHCFC |
| ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | E3 ubiquitin-protein ligase TRIM63 antibody FLJ32380 antibody IRF antibody Iris RING finger protein antibody MURF 1 antibody MURF-1 antibody MuRF1 antibody MURF2 antibody Muscle specific ring finger protein 1 antibody Muscle specific ring finger protein 2 antibody Muscle-specific RING finger protein 1 antibody OTTHUMP00000008701 antibody RING finger protein 28 antibody RNF 28 antibody RNF28 antibody SMRZ antibody Striated muscle RING zinc finger protein antibody TRI63_HUMAN antibody TRIM 63 antibody Trim63 antibody Tripartite motif containing 63 antibody tripartite motif containing 63 E3 ubiquitin protein ligase antibody Tripartite motif containing protein 63 antibody Tripartite motif-containing protein 63 antibody Ubiquitin ligase TRIM63 antibody |
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| Molecular Weight(MW) | 40 kDa |
| Cellular Localization | Cytoplasm. Nucleus |
| SwissProt ID | Q969Q1 |
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Application
Fig1:ICC?staining?MuRF1(green)?and?Actin? filaments?(red)?in?Hela?cells.?The?nuclear?counter?stain?is?DAPI?(blue).?Cells?were?fixed?in?paraformaldehyde,?permeabilised? with?0.25%?Triton?X100/PBS.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti-MuRF1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded huamn muscle tissues? using anti-MuRF1 antibody. Counter stained with hematoxylin.
Application
Fig4: Flow cytometric analysis of Hela cells with MuRF1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Hela, rectum cancer tissues.muscle tissues. |
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| Application Notes | ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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