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| Product Name | WASF2 [SC66-05] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | DICTYOSTELIUM antibody dJ393P12.2 antibody IMD2 antibody Protein WAVE-2 antibody Putative Wiskott Aldrich syndrome protein family member 4 antibody SCAR 2 antibody SCAR antibody SCAR2 antibody Suppressor of cyclic-AMP receptor (WASP family) antibody Verprolin homology domain-containing protein 2 antibody WASF2 antibody WASF2_HUMAN antibody WASF4 antibody WASP family protein member 2 antibody WASP family protein member 4 antibody WASP family Verprolin homologous protein 2 antibody WASP-family protein member 2 antibody WAVE 2 antibody WAVE2 antibody Wiskott-Aldrich syndrome protein family member 2 antibody Wiskott-Aldrich syndrome protein family verprolin-homologous protein antibody |
| Product description | WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | DICTYOSTELIUM antibody dJ393P12.2 antibody IMD2 antibody Protein WAVE-2 antibody Putative Wiskott Aldrich syndrome protein family member 4 antibody SCAR 2 antibody SCAR antibody SCAR2 antibody Suppressor of cyclic-AMP receptor (WASP family) antibody Verprolin homology domain-containing protein 2 antibody WASF2 antibody WASF2_HUMAN antibody WASF4 antibody WASP family protein member 2 antibody WASP family protein member 4 antibody WASP family Verprolin homologous protein 2 antibody WASP-family protein member 2 antibody WAVE 2 antibody WAVE2 antibody Wiskott-Aldrich syndrome protein family member 2 antibody Wiskott-Aldrich syndrome protein family verprolin-homologous protein antibody |
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| Molecular Weight(MW) | 54 kDa |
| Cellular Localization | Cytoplasm, Cell projection. |
Application
Fig1: Western blot analysis of WASF2 on human placenta lysates using anti-WASF2 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-WASF2 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-WASF2 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-WASF2 antibody. Counter stained with hematoxylin.| Positive Control | Human placenta tissue, human kidney tissue, mouse kidney tissue, mouse placenta tissue. |
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| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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