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| Product Name | CD44 [ST57-03] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | LHR antibody BA-1 antibody CD 44 antibody CD44 antibody CD44 antigen antibody CD44 molecule (Indian blood group) antibody CD44 molecule antibody CD44_HUMAN antibody CDw44 antibody Cell surface glycoprotein CD44 antibody chondroitin sulfate proteoglycan 8 antibody CSPG8 antibody ECMR-III antibody Epican antibody Extracellular matrix receptor III antibody GP90 lymphocyte homing/adhesion receptor antibody HCELL antibody hematopoietic cell E- and L-selectin ligand antibody Heparan sulfate proteoglycan antibody Hermes antigen antibody homing function and Indian blood group system antibody HSA antibody HUTCH-I antibody HUTCH1 antibody Hyaluronate receptor antibody IN antibody MC56 antibody MDU2 antibody MDU3 antibody MGC10468 antibody MIC4 antibody MUTCH1 antibody PGP-1 antibody PGP-I antibody PGP1 antibody Phagocytic glycoprotein 1 antibody Phagocytic glycoprotein I antibody Soluble CD44 antibody |
| Product description | Cell adhesion molecules (CAMs) are a family of closely related, cell surface glycoproteins that are involved in cell-cell interactions and are thought to play an important role in embryogenesis and development. HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I or ECMR-III, is a 742 amino acid single-pass type I membrane protein that is involved in hematopoiesis, lymphocyte activation and tumor metastasis. Functioning as a receptor for hyaluronic acid (HA) and interacting with ligands such as osteopontin (OPN), HCAM mediates both cell-cell and cell-matrix interactions, thereby playing an essential role in cell adhesion and cell migration. HCAM contains one Link domain and, due to alternative splicing events, is expressed as multiple isoforms, some of which are designated CD44R, CDw44, CD44S, CD44H (hematopoietic) and CD44E (epithelial). While most of the HCAM splice varients are expressed in tissues throughout the body, one specific isoform, namely CD44H, is expressed at high levels in cancer tissue, suggesting an important role for the CD44H splice varient in tumor progression. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCFC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200: FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | LHR antibody BA-1 antibody CD 44 antibody CD44 antibody CD44 antigen antibody CD44 molecule (Indian blood group) antibody CD44 molecule antibody CD44_HUMAN antibody CDw44 antibody Cell surface glycoprotein CD44 antibody chondroitin sulfate proteoglycan 8 antibody CSPG8 antibody ECMR-III antibody Epican antibody Extracellular matrix receptor III antibody GP90 lymphocyte homing/adhesion receptor antibody HCELL antibody hematopoietic cell E- and L-selectin ligand antibody Heparan sulfate proteoglycan antibody Hermes antigen antibody homing function and Indian blood group system antibody HSA antibody HUTCH-I antibody HUTCH1 antibody Hyaluronate receptor antibody IN antibody MC56 antibody MDU2 antibody MDU3 antibody MGC10468 antibody MIC4 antibody MUTCH1 antibody PGP-1 antibody PGP-I antibody PGP1 antibody Phagocytic glycoprotein 1 antibody Phagocytic glycoprotein I antibody Soluble CD44 antibody |
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| Molecular Weight(MW) | 82 kDa |
| Cellular Localization | Cell membrane. |
| SwissProt ID | P16070 |
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Application
Fig1: Western blot analysis of CD44 on different lysates using anti-CD44 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Jurkat
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-CD44 antibody. Counter stained with hematoxylin.
Application
Fig7: Flow cytometric analysis of Hela cells with CD44 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.| Positive Control | Jurkat, Hela, human tonsil tissue, human colon cancer tissue, human spleen tissue, mouse colon tissue, human breast carcinoma tissue. |
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| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200: FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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