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| Product Name | PBP [SC58-09] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | Epididymis luminal protein 210 antibody Epididymis secretory protein Li 34 antibody Epididymis secretory protein Li 96 antibody HCNP antibody HCNPpp antibody HEL 210 antibody HEL S 34 antibody HEL S 96 antibody Hippocampal cholinergic neurostimulating peptide antibody Neuropolypeptide h3 antibody PBP antibody PEBP antibody PEBP 1 antibody PEBP-1 antibody Pebp1 antibody PEBP1_HUMAN antibody Phosphatidylethanolamine binding protein antibody Phosphatidylethanolamine binding protein 1 antibody Prostatic binding protein antibody Prostatic-binding protein antibody R kip antibody Raf kinase inhibitor protein antibody Raf kinase inhibitory protein antibody RKIP antibody |
| Product description | Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a(lpha)-chemokine family, resides in the a(lpha)-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHCIP |
| WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | Epididymis luminal protein 210 antibody Epididymis secretory protein Li 34 antibody Epididymis secretory protein Li 96 antibody HCNP antibody HCNPpp antibody HEL 210 antibody HEL S 34 antibody HEL S 96 antibody Hippocampal cholinergic neurostimulating peptide antibody Neuropolypeptide h3 antibody PBP antibody PEBP antibody PEBP 1 antibody PEBP-1 antibody Pebp1 antibody PEBP1_HUMAN antibody Phosphatidylethanolamine binding protein antibody Phosphatidylethanolamine binding protein 1 antibody Prostatic binding protein antibody Prostatic-binding protein antibody R kip antibody Raf kinase inhibitor protein antibody Raf kinase inhibitory protein antibody RKIP antibody |
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| Molecular Weight(MW) | 21 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of PBP on mouse brain lysates using anti-PBP antibody at 1/1,000 dilution.
Application
Fig2: ICC staining PBP in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PBP antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PBP antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-PBP antibody. Counter stained with hematoxylin.| Positive Control | PC-3M, human kidney tissue, mouse brain tissue, mouse kidney tissue. |
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| Application Notes | WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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