| 存储条件 |
|---|
| Product Name | HDAC1 [SY12-04] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKFZp686H12203 antibody GON 10 antibody HD1 antibody HDAC 1 antibody HDAC1 antibody HDAC1_HUMAN antibody Histone deacetylase 1 antibody Reduced potassium dependency yeast homolog like 1 antibody RPD3 antibody RPD3L1 antibody |
| Product description | Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHC |
| WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | DKFZp686H12203 antibody GON 10 antibody HD1 antibody HDAC 1 antibody HDAC1 antibody HDAC1_HUMAN antibody Histone deacetylase 1 antibody Reduced potassium dependency yeast homolog like 1 antibody RPD3 antibody RPD3L1 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| Cellular Localization | Nucleus. |
Application
Fig1: Western blot analysis of HDAC1 on different lysates using anti-HDAC1 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Jurkat Lane 3: K562
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-HDAC1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-HDAC1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-HDAC1 antibody. Counter stained with hematoxylin.| Positive Control | K562, Hela, Jurkat, human tonsil tissue, mouse colon tissue, mouse pancreas tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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