| 存储条件 |
|---|
| Product Name | CaMKII delta |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2influx into the myocyte, Ca2release from the sarcoplasmic reticulum (SR), SR Ca2uptake and Naand Kchannel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Regulates Ca2influx to myocytes by binding and phosphorylating the L-type Ca2channel subunit beta-2 CACNB2. In addition to Ca2channels, can target and regulate the cardiac sarcolemmal Nachannel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC |
| WB:1:500-1:2,000 IHC | |
| Species Reactivity | Human,Mouse,Rat,Zebra Fish |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | Calcium / calmodulin dependent protein kinase 2 delta antibody Calcium / calmodulin dependent protein kinase II delta antibody calcium/calmodulin-dependent protein kinase (CaM kinase) II delta antibody calcium/calmodulin-dependent protein kinase type II delta chain antibody Calcium/calmodulin-dependent protein kinase type II subunit delta antibody CAM kinase 2 delta antibody CAM kinase II delta antibody CaM kinase II delta subunit antibody CaM kinase II subunit delta antibody CaM-kinase II delta chain antibody CAMK 2d antibody CaMK-II delta subunit antibody CaMK-II subunit delta antibody CAMK2D antibody CAMKD antibody CAMKI antibody KCC2D_HUMAN antibody RATCAMKI antibody |
|---|---|
| Molecular Weight(MW) | 50 kDa |
| Cellular Localization | Cell membrane. Cytoplasm. |
Application
Fig1: Western blot analysis of CaMKII delta on Human skeletal muscle (1) and Rat heart (2) cells lysates using anti-CaMKII delta antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded zebrafish tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.| Positive Control | Human skeletal muscle tissue lysate, rat heart tissue lysate, zebrafish tissue, rat brain tissue, mouse heart tissue, mouse skeletal muscle tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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