| 存储条件 |
|---|
| Product Name | Insulin degrading enzyme [JJ0949] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Abeta-degrading protease antibody FLJ35968 antibody Ide antibody IDE_HUMAN antibody Insulin protease antibody Insulin-degrading enzyme antibody Insulinase antibody Insulysin antibody OTTHUMP00000020097 antibody |
| Product description | Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin response and resistance. IDE is a highly conserved thiol metalloprotease with ubiquitous expression including the brain. Since its discovery, IDE has been shown to degrade a variety of bioactive peptides. Recently the finding that IDE clears intracellular and extracellular amyloid products has spurred research into the link between IDE function and human neurodegenerative disease such as Alzheimer’s. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRatZebra Fish |
| Concentration | 1mg/ml |
| Alternative Names | Abeta-degrading protease antibody FLJ35968 antibody Ide antibody IDE_HUMAN antibody Insulin protease antibody Insulin-degrading enzyme antibody Insulinase antibody Insulysin antibody OTTHUMP00000020097 antibody |
|---|---|
| Molecular Weight(MW) | 118 kDa |
| Cellular Localization | Cytoplasm, Cell membrane, Secreted. |
Application
Fig1: Western blot analysis of Insulin degrading enzyme on different lysates using anti-Insulin degrading enzyme antibody at 1/1,000 dilution. Positive control: Lane 1: zebrafish Lane 2: Hela Lane 3: K562
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Insulin degrading enzyme antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Insulin degrading enzyme antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-Insulin degrading enzyme antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Insulin degrading enzyme antibody. Counter stained with hematoxylin.
Application
Fig6:Western blot analysis of Insulin degrading enzyme on hybrid fish (crucian-carp) heart tissue lysate using anti-Insulin degrading enzyme antibody at 1/500 dilution.| Positive Control | K562, Hela, zebrafish, human liver cancer tissue, human colon cancer tissue, human gastric carcinoma tissue, mouse colon tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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