| 存储条件 |
|---|
| Product Name | STIM1 Polyclonal antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | STIM1 Fusion Protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCWB |
| WB:1:1000-1:5000 IHC:1:20-1:200 ICC:1:200-1:800 | |
| Species Reactivity | HumanMouseRat |
| Purification | Affinity purified |
| Gene Symbol | STIM1 |
|---|---|
| Gene Synonyms | GOK TAM TAM1 IMD10 STRMK D11S4896E |
| Gene Full Name | stromal interaction molecule 1 |
| Gene Summary | This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
| Alternative Names | GOK IMD10 STIM 1 stim-1 STRMK |
| Molecular Weight(MW) | ObservedMW: 77-90 kDa |
WB
Variouslysates were subjected to SDS PAGE followed by western blot with STIM1 antibody at dilution of 1:2500 incubated at room temperature for 1.5 hours.
IHC
Immunohistochemical analysis of paraffin-embedded human ovary tumor using STIM1 antibody at dilution of 1:50 (under 40x lens).
ICC/IF
Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using STIM1 antibody at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).| Application Notes | WB:1:1000-1:5000 IHC:1:20-1:200 ICC:1:200-1:800 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
抱歉，暂无相关文献
