| 存储条件 |
|---|
| Product Name | NR0B2 Rabbit pAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant fusion protein containing a sequence of human NR0B2 (NP_068804.1). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCWB |
| WB:1:500-1:1000 IHC:1:50-1:100 ICC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | NR0B2 |
|---|---|
| Gene Synonyms | NR0B2 SHP SHP1 nuclear receptor subfamily 0 group B member 2 |
| Gene Full Name | nuclear receptor subfamily 0 group B member 2 |
| Gene Summary | The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] |
| Alternative Names | NR0B2 |
| Molecular Weight(MW) | 28 kDa |
| Cellular Localization | Nucleus,Cytoplasm. |
WB
Western blot analysis of NR0B2 in various cell lines lysates using NR0B2 antibody.
IHC
Immunohistochemistry analysis of paraffin-embedded rat liver using NR0B2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ICC/IF
Immunofluorescence analysis of NR0B2 in U2OS cells using NRB2 antibody,and DAPI (blue).| Application Notes | WB:1:500-1:1000 IHC:1:50-1:100 ICC:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | iquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
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