CK 2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody
Product description
The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIHC
WB:1:1,000 IHC:1:50-1:200
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Alternative Names
CK 2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody
