Matrilin 1, cartilage matrix protein, also known as MATN1, is a protein which in humans is encoded by the MATN1 gene. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Three microsatellite polymorphisms in the gene, respectively consisting of 103 bp, 101 bp and 99 bp, have been linked to idiopathic scoliosis.
Fig1: Western blot analysis of MATN1 on HEK293 (1) and MATN1-hIgGFc transfected HEK293 (2) cell lysate using anti-MATN1 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining MATN1 (green) and actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
