| 存储条件 |
|---|
| Product Name | CD276 [C10-A1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 4Ig B7 H3 antibody 4Ig-B7-H3 antibody AU016588 antibody B7 H3 antibody B7 homolog 3 antibody B7-H3 antibody B7H3 antibody B7RP-2 antibody CD_antigen=CD276 antibody CD276 antibody CD276 antigen antibody CD276 molecule antibody CD276_HUMAN antibody Costimulatory molecule antibody Flags: Precursor antibody PSEC0249 antibody UNQ309/PRO352 antibody |
| Product description | T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 Immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 4Ig B7 H3 antibody 4Ig-B7-H3 antibody AU016588 antibody B7 H3 antibody B7 homolog 3 antibody B7-H3 antibody B7H3 antibody B7RP-2 antibody CD_antigen=CD276 antibody CD276 antibody CD276 antigen antibody CD276 molecule antibody CD276_HUMAN antibody Costimulatory molecule antibody Flags: Precursor antibody PSEC0249 antibody UNQ309/PRO352 antibody |
|---|---|
| Molecular Weight(MW) | 57 kDa |
| Cellular Localization | Membrane. |
| SwissProt ID | Q5ZPR3 |
|---|
Application
Fig1: Western blot analysis of CD276 on HEK293 (1) and CD276-hIgGFc transfected HEK293 (2) cell lysate using anti-CD276 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-CD276 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-CD276 antibody. Counter stained with hematoxylin.
Application
Fig4: Flow cytometric analysis of PC-3 cells with CD276 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).| Positive Control | CD276-hIgGFc transfected HEK293 cell lysate, human cervical cancer tissue, human ovarian cancer tissue, PC-3. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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