| 存储条件 |
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| Product Name | SOX2 [C9-F10] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ANOP3 antibody cb236 antibody Delta EF2a antibody lcc antibody MCOPS3 antibody MGC148683 antibody MGC2413 antibody RGD1565646 antibody Sex determining region Y box 2 antibody SOX 2 antibody Sox2 antibody SOX2_HUMAN antibody SRY (sex determining region Y) box 2 antibody SRY box containing gene 2 antibody SRY related HMG box 2 antibody SRY related HMG box gene 2 antibody SRY-box 2 antibody Transcription factor SOX 2 antibody Transcription factor SOX-2 antibody ysb antibody |
| Product description | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| WB:1:250~1:1000 ICC:1:100~1:200 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | ANOP3 antibody cb236 antibody Delta EF2a antibody lcc antibody MCOPS3 antibody MGC148683 antibody MGC2413 antibody RGD1565646 antibody Sex determining region Y box 2 antibody SOX 2 antibody Sox2 antibody SOX2_HUMAN antibody SRY (sex determining region Y) box 2 antibody SRY box containing gene 2 antibody SRY related HMG box 2 antibody SRY related HMG box gene 2 antibody SRY-box 2 antibody Transcription factor SOX 2 antibody Transcription factor SOX-2 antibody ysb antibody |
|---|---|
| Molecular Weight(MW) | 34 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | P48431 |
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Application
Fig1: Western blot analysis of SOX2 on HEK293 (1) and SOX2-hIgGFc transfected HEK293 (2) cell lysate using anti-SOX2 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining SOX2 (green) and Actin filaments (red) in NTERA-2 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-SOX2 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue using anti-SOX2 antibody. Counter stained with hematoxylin.| Positive Control | SOX2-hIgGFc transfected HEK293 cell lysate, human lung cancer tissue, human esophageal cancer tissue, NTERA-2. |
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| Application Notes | WB:1:250~1:1000 ICC:1:100~1:200 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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