| 存储条件 |
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| Product Name | AP2 beta [G1-F7] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Activating enhancer binding protein 2 beta antibody Activating enhancer-binding protein 2-beta antibody AP 2B antibody AP2 B antibody AP2-beta antibody AP2B antibody AP2B_HUMAN antibody AP2beta antibody MGC21381 antibody OTTHUMP00000039925 antibody PDA2 antibody TFAP 2B antibody Tfap2b antibody Transcription factor AP 2 beta antibody Transcription factor AP-2-beta antibody Transcription factor AP2 beta antibody |
| Product description | AP-2 transcription factor family members include AP-2α, AP-2β and AP-2γ, which specifically bind to the DNA consensus sequence CCCCAGGC and initiate transcription of selected genes. AP-2, also known as ERF-1, plays a role in regulating estrogen receptor expression. AP-2β, a splice variant of AP-2α, inhibits AP-2 activity. Besides subscribing to the AP-2 complex, AP-2α, AP-2β and AP-2γ proteins compose the OB2-1 transcription factor complex. OB2-1 specifically upregulates expression of the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2α may play an important role in the development of ectodermal-derived tissues. Deleterious mutations involving the AP-2α gene are linked to microphthalmia, corneal clouding and other anterior eye chamber defects. The ubiquitously expressed AP-4 transcription factor specifically binds to the DNA consensus sequence 5'-CAGCTG-3'. AP-4 interacts with promoters for immunoglobulin-κ gene families and simian virus 40. AP-4 may enhance the transcription of the human Huntington's disease gene. AP-4 is a helix-loop-helix protein that contains two distinctive leucine repeat elements. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Activating enhancer binding protein 2 beta antibody Activating enhancer-binding protein 2-beta antibody AP 2B antibody AP2 B antibody AP2-beta antibody AP2B antibody AP2B_HUMAN antibody AP2beta antibody MGC21381 antibody OTTHUMP00000039925 antibody PDA2 antibody TFAP 2B antibody Tfap2b antibody Transcription factor AP 2 beta antibody Transcription factor AP-2-beta antibody Transcription factor AP2 beta antibody |
|---|---|
| Molecular Weight(MW) | 50 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | Q92481 |
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Application
Fig1: Western blot analysis of AP2 beta on human AP2 beta recombinant protein using anti- AP2 beta antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of AP2 beta on HEK293 (1) and AP2 beta -hIgGFc transfected HEK293 (2) cell lysate using anti- AP2 beta antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of AP2 beta on ?SK-N-SH cell lysate using anti- AP2 beta antibody at 1/1,000 dilution.
Application
Fig4:Flow cytometric analysis of SK-N-SH cells with AP2 beta antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human AP2 beta recombinant protein, AP2 beta -hIgGFc transfected HEK293 cell lysate, SK-N-SH. |
|---|---|
| Application Notes | WB:1:500-1:2,000 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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