| 存储条件 |
|---|
| Product Name | FOXP2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CAG repeat protein 44 antibody CAGH44 antibody DKFZp686H1726 antibody Forkhead box P2 antibody Forkhead box protein P2 antibody forkhead/winged-helix transcription factor antibody FOX P2 antibody FOXP2 antibody FOXP2_HUMAN antibody HGNC11222 antibody HGNC11956 antibody SPCH 1 antibody SPCH1 antibody TNRC 10 antibody TNRC10 antibody trinucleotide repeat containing 10 antibody Trinucleotide repeat containing gene 10 protein antibody Trinucleotide repeat-containing gene 10 protein antibody |
| Product description | The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | CAG repeat protein 44 antibody CAGH44 antibody DKFZp686H1726 antibody Forkhead box P2 antibody Forkhead box protein P2 antibody forkhead/winged-helix transcription factor antibody FOX P2 antibody FOXP2 antibody FOXP2_HUMAN antibody HGNC11222 antibody HGNC11956 antibody SPCH 1 antibody SPCH1 antibody TNRC 10 antibody TNRC10 antibody trinucleotide repeat containing 10 antibody Trinucleotide repeat containing gene 10 protein antibody Trinucleotide repeat-containing gene 10 protein antibody |
|---|---|
| Molecular Weight(MW) | 80 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | O15409 |
|---|
Application
Fig1: Western blot analysis of FOXP2 on human FOXP2 recombinant protein using anti-FOXP2 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of FOXP2 on HEK293 (1) and FOXP2-hIgGFc transfected HEK293 (2) cell lysate using anti-FOXP2 antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of FOXP2 on HepG2 cell lysate using anti-FOXP2 antibody at 1/1,000 dilution.
Application
Fig4:Flow cytometric analysis of Hela cells with FOXP2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human FOXP2 recombinant protein, FOXP2-hIgGFc transfected HEK293 cell lysate, HepG2, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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