| 存储条件 |
|---|
| Product Name | DHX58 [A3-A6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | D11LGP2 antibody D11lgp2e antibody DEXH (Asp Glu X His) box polypeptide 58 antibody DEXH box polypeptide 58 antibody DHX 58 antibody DHX58 antibody DHX58_HUMAN antibody LGP 2 antibody LGP2 antibody Ortholog of mouse D11lgp2 antibody Probable ATP dependent helicase LGP2 antibody Probable ATP dependent RNA helicase DHX58 antibody Probable ATP-dependent helicase LGP2 antibody Probable ATP-dependent RNA helicase DHX58 antibody Protein D11Lgp2 homolog antibody RIG-I-like receptor LGP2 antibody RLR antibody RNA helicase LGP2 antibody |
| Product description | Helicases are enzymes that catalyze the separation of double stranded DNA or RNA by utilizing ATP. LGP2, also known as probable ATP-dependent RNA helicase DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | D11LGP2 antibody D11lgp2e antibody DEXH (Asp Glu X His) box polypeptide 58 antibody DEXH box polypeptide 58 antibody DHX 58 antibody DHX58 antibody DHX58_HUMAN antibody LGP 2 antibody LGP2 antibody Ortholog of mouse D11lgp2 antibody Probable ATP dependent helicase LGP2 antibody Probable ATP dependent RNA helicase DHX58 antibody Probable ATP-dependent helicase LGP2 antibody Probable ATP-dependent RNA helicase DHX58 antibody Protein D11Lgp2 homolog antibody RIG-I-like receptor LGP2 antibody RLR antibody RNA helicase LGP2 antibody |
|---|---|
| Molecular Weight(MW) | 77 kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | Q96C10 |
|---|
Application
Fig1: Western blot analysis of DHX58 on human DHX58 recombinant protein using anti-DHX58 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of DHX58 on HEK293 (1) and DHX58-hIgGFc transfected HEK293 (2) cell lysate using anti-DHX58 antibody at 1/1,000 dilution.
Application
Fig3: Flow cytometric analysis of Hela cells with DHX58 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human DHX58 recombinant protein, DHX58-hIgGFc transfected HEK293 cell lysate, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 FC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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