ASRT5 antibody IL 1 receptor associated kinase M antibody IL-1 receptor-associated kinase M antibody IL1 receptor associated kinase M antibody Interleukin 1 receptor associated kinase 3 antibody Interleukin 1 receptor associated kinase M antibody Interleukin-1 receptor-associated kinase 3 antibody IRAK M antibody IRAK-3 antibody IRAK-M antibody Irak3 antibody IRAK3_HUMAN antibody
Product description
Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. An IL-1-dependent kinase termed IRAK-1 (for IL-1 receptor- associated kinase 1) coimmunoprecipitates with activated IL-1RI and is implicated as an upstream mediator of NFkB activation. A related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFkB. IRAK-2 is a proximal mediator of IL1, a component of the IL1R signaling complex, and is required for IL1R-induced NFkB activation. IRAK-4, like IRAK-1 and Pelle, has auto- and cross-phosphorylation kinase activity. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells. IRAK-M mRNA transcripts are found predominantly in PBL and the monocytic cell lines U937 and THP-1.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIP
WB:1:1,000-1:2,000
Species Reactivity
Human
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
ASRT5 antibody IL 1 receptor associated kinase M antibody IL-1 receptor-associated kinase M antibody IL1 receptor associated kinase M antibody Interleukin 1 receptor associated kinase 3 antibody Interleukin 1 receptor associated kinase M antibody Interleukin-1 receptor-associated kinase 3 antibody IRAK M antibody IRAK-3 antibody IRAK-M antibody Irak3 antibody IRAK3_HUMAN antibody
Fig1: Western blot analysis of IRAKM on different lysates using anti-IRAKM antibody at 1/1,000 dilution. Positive control: Lane 1: Human placenta Lane 2: Human thyroid
Positive Control
Human placenta tissue, human thyroid tissue.
Application Notes
WB:1:1,000-1:2,000
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
