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| Product Name | ACVR1 [C11-E2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Activin A receptor type I antibody Activin A receptor type II like kinase 2 antibody Activin receptor type I antibody Activin receptor type-1 antibody Activin receptor-like kinase 2 antibody ACTR-I antibody ACTRI antibody Acvr1 antibody ACVR1_HUMAN antibody ACVR1A antibody ACVRLK2 antibody ALK 2 antibody ALK-2 antibody ALK2 antibody FOP antibody Hydroxyalkyl protein kinase antibody Serine/threonine-protein kinase receptor R1 antibody SKR1 antibody TGF-B superfamily receptor type I antibody TGFB superfamily receptor type I antibody TSR-I antibody TSRI antibody |
| Product description | Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Activin A receptor type I antibody Activin A receptor type II like kinase 2 antibody Activin receptor type I antibody Activin receptor type-1 antibody Activin receptor-like kinase 2 antibody ACTR-I antibody ACTRI antibody Acvr1 antibody ACVR1_HUMAN antibody ACVR1A antibody ACVRLK2 antibody ALK 2 antibody ALK-2 antibody ALK2 antibody FOP antibody Hydroxyalkyl protein kinase antibody Serine/threonine-protein kinase receptor R1 antibody SKR1 antibody TGF-B superfamily receptor type I antibody TGFB superfamily receptor type I antibody TSR-I antibody TSRI antibody |
|---|---|
| Molecular Weight(MW) | 57 kDa |
| Cellular Localization | Membrane |
| SwissProt ID | Q04771 |
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Application
Fig1: Western blot analysis of ACVR1 on human ACVR1 recombinant protein using anti-ACVR1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of ACVR1 on HEK293 (1) and ACVR1-hIgGFc transfected HEK293 (2) cell lysate using anti-ACVR1 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-ACVR1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-ACVR1 antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of Hela cells with ACVR1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human ACVR1 recombinant protein, ACVR1-hIgGFc transfected HEK293 cell lysate, human ovarian cancer tissue, human endometrial cancer tissue, Hela, |
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| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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