| 存储条件 |
|---|
| Product Name | ALDH4A1 [7E2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures. |
| Immunogen | Synthetic peptide of C terminal human ALDH4A1. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WB,IHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | Human,Rat |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | AL4A1_HUMAN antibody aldehyde dehydrogenase 4 antibody aldehyde dehydrogenase 4 family member A1 antibody Aldehyde dehydrogenase family 4 member A1 antibody Aldehyde dehydrogenase family 4 subfamily A member 1 antibody ALDH4 antibody aldh4a1 antibody Delta 1 pyrroline 5 carboxylate dehydrogenase mitochondrial antibody Delta-1-pyrroline-5-carboxylate dehydrogenase antibody L-glutamate gamma-semialdehyde dehydrogenase antibody mitochondrial antibody mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody P5C dehydrogenase antibody P5CD antibody P5CDh antibody P5CDhL antibody P5CDhS antibody Pyrroline-5-carboxylate dehydrogenase antibody RP11 128M10.1 antibody |
|---|---|
| Molecular Weight(MW) | 62 kDa |
| Cellular Localization | Mitochondrion. |
Application
Fig1: Western blot analysis of ALDH4A1 on SK-Br-3 (1) and HepG2 (2) cell lysate using anti-ALDH4A1 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.| Positive Control | SK-Br-3, HepG2, human liver tissue, human colon cancer tissue, human prostate tissue, human kidney tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
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