| 存储条件 |
|---|
| Product Name | KCNQ4 Mouse Monoclonal Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Fusion protein amino acids 2-77 of human KCNQ4 |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB:1:1000 IHC:1:100 | |
| Species Reactivity | HumanMonkeyRat |
| Purification | Protein G |
| Gene Symbol | KCNQ4 |
|---|---|
| Gene Synonyms | DFNA2 KV7.4 DFNA2A |
| Gene Full Name | potassium voltage-gated channel subfamily Q member 4 |
| Gene Summary | The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | DFNA2 DFNA2A KV7.4 |
| Molecular Weight(MW) | 77kDa |
| Cellular Localization | Basal cell membrane. |
WB
Western blot analysis of KCNQ4 in rat tissue lysates using a 1:1000 dilution of the antibody.
IHC
IHC analysis of KCNQ4 in frozen sections of mouse brain extract using the antibody.| Application Notes | WB:1:1000 IHC:1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C as received. |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide. |
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