Synthesized peptide derived from human FILA2 AA range: 402-452
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB:1:500-1:2000
Species Reactivity
HumanMouse
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Symbol
FLG2
Gene Synonyms
IFPS PSS6
Gene Full Name
filaggrin 2
Gene Summary
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020]
Molecular Weight(MW)
263kDa
Cellular Localization
Cytoplasm . Cytoplasmic granule .
Application
WB
Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night.
