CD19 is a 95 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily (PMID: 2472450). It is expressed by B cells and follicular dendritic cells. CD19 is up-regulated at the step of B-lineage commitment during the differentiation of the hematopoietic stem cell, it remains on during subsequent stages of differentiation until finally down-regulated during terminal differentiation into plasma cells (PMID: 8528044). CD19 is involved in B cell development, activation and differentiation. It is the dominant component for the signaling complex on B cells that includes CD21 (CR2), CD81 (TAPA-1) and CD225 and acts as a critical co-receptor for BCR signal transduction (PMID: 23210908).
Alternative Names
1D3 B-lymphocyte antigen CD19 CD19 antigen
Application
FC
1X10^6 C57BL/6 mouse splenocytes were surface co-stained with Anti-Mouse CD3 and 0.5 ug Anti-Mouse CD19 or 0.5 ug Rat IgG2a Isotype Control, and FITC anti-rat IgG2a Antibody at dilution 1:100. Cells were not fixed.
Application Notes
FC:1:100
Additional Information
Form
Liquid
Storage Instructions
Store at 2-8°C. Stable for one year after shipment.
