| 存储条件 |
|---|
| Product Name | Anti-Mouse CD8a |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Spleen cells or thymocyte membranes |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a,k |
| Host Species | Rat |
| Tested Applications | FC |
| FC:1:100 | |
| Species Reactivity | Mouse |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Cd8a |
|---|---|
| Gene Synonyms | Ly-2 Ly-B Ly-35 Lyt-2 |
| Gene Full Name | CD8 subunit alpha |
| Target Description | CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). |
| Alternative Names | CD8 53-6.7 CD8 antigen alpha chain CD8α Ly 2 |
FC
1X10^6 C57BL/6 mouse splenocytes were surface stained with Anti-Mouse CD3 and 0.5 ug Anti-Mouse CD8a or 0.5 ug Rat IgG2a Isotype Control and FITC anti-rat IgG2a Antibody at dilution 1:100. Cells were not fixed.| Application Notes | FC:1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Stable for one year after shipment. |
| Storage Buffer | Borate buffered saline, pH 8.2. |
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