| 存储条件 |
|---|
| Product Name | Mouse monoclonal antibody to UBE3A |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | UBE3A (AAH09271, 51 a.a. ~ 150 a.a) partial recombinant protein with GST tag. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHCWB |
| WB:1:500-1:1000 IHC:3ug/ml ICC:10ug/ml | |
| Species Reactivity | HumanRat |
| Purification | Affinity purified |
| Gene Symbol | UBE3A |
|---|---|
| Gene Synonyms | AS ANCR PIX1 E6-AP HPVE6A EPVE6AP |
| Gene Full Name | ubiquitin protein ligase E3A |
| Gene Summary | This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| Alternative Names | Ubiquitin-protein ligase E3A 632- E6AP ubiquitin-protein ligase Human papillomavirus E6-associated protein Oncogenic protein-associated protein E6-AP Renal carcinoma antigen NY-REN-54 UBE3A E6AP EPVE6AP HPVE6A |
| Molecular Weight(MW) | 100kDa |
| Cellular Localization | Cytoplasm,Nucleus. |
WB
UBE3A monoclonal antibody, clone 2F6 Western Blot analysis of UBE3A expression in Jurkat.
IHC
Immunoperoxidase of monoclonal antibody to UBE3A on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml]
ICC/IF
Immunofluorescence of monoclonal antibody to UBE3A on HeLa cell. [antibody concentration 10 ug/ml]| Application Notes | WB:1:500-1:1000 IHC:3ug/ml ICC:10ug/ml |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
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