| 存储条件 |
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| Product Name | SELK (SELENOK) Rabbit Polyclonal Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | SELK antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SELK. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IF-PWB |
| WB:1-2 ug/ml IF-P:20 ug/ml | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SELENOK |
|---|---|
| Gene Synonyms | SELK HSPC030 HSPC297 |
| Gene Full Name | selenoprotein K |
| Gene Summary | The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017] |
| Alternative Names | HSPC030 HSPC297 |
| Molecular Weight(MW) | 10kDa |
| Cellular Localization | Endoplasmic reticulum membrane,Cell membrane. |
WB
Western blot analysis of SELK in A20 cell lysate with SELK antibody at (A) 1 and (B) 2 ug/ml.
IF-P
Immunofluorescence of SELK in human heart tissue with SELK antibody at 20 ug/ml.| Application Notes | WB:1-2 ug/ml IF-P:20 ug/ml |
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| Form | Liquid |
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| Storage Instructions | Store at -20°C as received. |
| Storage Buffer | SELK Antibody is supplied in PBS containing 0.02% sodium azide. |
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