| 存储条件 |
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| Product Name | JAK1 [1G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | JAK 1 antibody JAK 1A antibody JAK 1B antibody JAK-1 antibody JAK1 antibody JAK1_HUMAN antibody JAK1A antibody JAK1B antibody Janus kinase 1 (a protein tyrosine kinase) antibody Janus kinase 1 antibody JTK3 antibody Tyrosine protein kinase JAK 1 antibody Tyrosine protein kinase JAK1 antibody Tyrosine-protein kinase JAK1 antibody |
| Product description | Jak1 (Janus kinase 1) belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak1. Jak1 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, Jak1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at position 1022 and 1023 is believed to function in the activation of catalytic events. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. |
| Immunogen | Amino acids 785-815 within an internal region of JAK1 of mouse origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | JAK 1 antibody JAK 1A antibody JAK 1B antibody JAK-1 antibody JAK1 antibody JAK1_HUMAN antibody JAK1A antibody JAK1B antibody Janus kinase 1 (a protein tyrosine kinase) antibody Janus kinase 1 antibody JTK3 antibody Tyrosine protein kinase JAK 1 antibody Tyrosine protein kinase JAK1 antibody Tyrosine-protein kinase JAK1 antibody |
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| Molecular Weight(MW) | 130kDa |
| Cellular Localization | Endomembrane system |
| SwissProt ID | P23458 |
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Application
Fig2： Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization (A). Immunoperoxidase staining of formalin fixed, paraffin-embedded Jurkat showing membrane and cytoplasmic localization (B).Application
Fig2： Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization (A). Immunoperoxidase staining of formalin fixed, paraffin-embedded Jurkat showing membrane and cytoplasmic localization (B).| Positive Control | 293T, Jurkat, Jurkat. |
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| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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