| 存储条件 |
|---|
| Product Name | TSC2/Tuberin |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FLJ43106 antibody LAM antibody OTTHUMP00000158940 antibody OTTHUMP00000198394 antibody OTTHUMP00000198395 antibody PPP1R160 antibody Protein phosphatase 1, regulatory subunit 160 antibody tsc2 antibody TSC2_HUMAN antibody TSC4 antibody TSC4 gene, formerly antibody TSC4, formerly antibody Tuberin antibody Tuberous sclerosis 2 antibody Tuberous sclerosis 2 protein antibody Tuberous sclerosis 2 protein homolog antibody |
| Product description | Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney. |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICCIHCFC |
| ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | FLJ43106 antibody LAM antibody OTTHUMP00000158940 antibody OTTHUMP00000198394 antibody OTTHUMP00000198395 antibody PPP1R160 antibody Protein phosphatase 1 regulatory subunit 160 antibody tsc2 antibody TSC2_HUMAN antibody TSC4 antibody TSC4 gene formerly antibody TSC4 formerly antibody Tuberin antibody Tuberous sclerosis 2 antibody Tuberous sclerosis 2 protein antibody Tuberous sclerosis 2 protein homolog antibody |
|---|---|
| Cellular Localization | Cytoplasm, Membrane |
| SwissProt ID | P49815 |
|---|
Application
Fig1： Immunocytochemical staining of SH-SY-5Y cells using anti-Tuberin rabbit polyclonal antibody.
Application
Fig2： Immunocytochemical staining of PANC-1 cells using anti-Tuberin rabbit polyclonal antibody.
Application
Fig3： Immunohistochemical analysis of paraffin- embedded human pancreas tissue using anti-Tuberin rabbit polyclonal antibody.
Application
Fig4： Immunohistochemical analysis of paraffin- embedded mouse liver tissue using anti-Tuberin rabbit polyclonal antibody.
Application
Fig5： Immunohistochemical analysis of paraffin- embedded human liver tissue using anti-Tuberin rabbit polyclonal antibody.
Application
Fig6： Immunohistochemical analysis of paraffin- embedded mouse pancreas tissue using anti-Tuberin rabbit polyclonal antibody.
Application
Fig7： Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-Tuberin rabbit polyclonal antibody.
Application
Fig8： Flow cytometric analysis of Hela cells with Tuberin antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary antibody.| Positive Control | SH-SY-5Y , PANC-1, human liver tissue, mouse brain tissue, human pancreas tissue, mouse pancreas tissue, mouse liver tissue. |
|---|---|
| Application Notes | ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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