Anti-ILP2抗体
兔多克隆抗体to ILP2
Rabbit
适用于: WB, ICCmore details
与反应: Human
Synthetic peptide:
TGYEARLITFGT
, corresponding to amino acids 2-13 of Human ILP2. (Peptide available as ab9665.)
WB: HepG2 and MOLT4 cell lysate. ICC: HepG2 cells
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 7.2
Preservative: 0.02% Sodium azide
浓度
100 µg 浓度为 1 mg/ml
Immunogen affinity purified
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
多克隆
IgG
Abpromise™承诺保证使用ab9664于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa. | |
| ICC | Use a concentration of 10 µg/ml. |
Entrez Gene: 112401 Human
SwissProt: Q96P09 Human
Unigene: 348263 Human
BIRC 8 antibody
BIRC8 antibody
BIRC8 protein antibody
BIRC8_HUMAN antibody
hILP 2 antibody
hILP2 antibody
IAP like protein 2 antibody
IAP-like protein 2 antibody
ILP 2 antibody
ILP-2 antibody
Inhibitor of apoptosis like protein 2 antibody
Inhibitor of apoptosis-like protein 2 antibody
Testis specific inhibitor of apoptosis antibody
Testis-specific inhibitor of apoptosis antibody
Baculoviral IAP repeat containing 8 antibody
Baculoviral IAP repeat containing protein 8 antibody
Baculoviral IAP repeat-containing protein 8 antibody
Western blot - Anti-ILP2 antibody (ab9664)
All lanes : Anti-ILP2 antibody (ab9664) at 1 µg/ml
Lane 1 : HepG2 cell lysate
Lane 2 : MOLT4 cell lysate
Immunocytochemistry - Anti-ILP2 antibody (ab9664)
ab9664 at 10µg/ml staining ILP2 in HepG2 cells by Immunocytochemistry.
