Anti-beta 2 Microglobulin antibody

• 产品名称

  Anti-beta 2 Microglobulin抗体
  参阅全部 beta 2 Microglobulin 一抗

• 描述

  兔多克隆抗体to beta 2 Microglobulin

• 宿主

  Rabbit

• 经测试应用

  适用于: WB, IHC-P, ICC/IFmore details

• 种属反应性

  与反应: Human
  

• 免疫原

  Full length native protein (purified) corresponding to Human beta 2 Microglobulin. beta 2 Microglobulin from human urine

• 常规说明

  The antibody reacts with b2-microglobulin isolated from human urine showing a 12.8 kDa band under non-reducing condition of SDS-PAGE.

  
  

  The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

  If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

• 形式

  Liquid

• 存放说明

  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

• 存储溶液

  Preservative: 0.01% Sodium azide
  Constituents: 0.424% Potassium phosphate solution, 0.88% Sodium chloride

• 纯度

  Ion Exchange Chromatography

• 纯化说明

  Anti-beta-2-Microglobulin antibody is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer.

• 克隆

  多克隆

• 同种型

  IgG

The Abpromise guarantee

Abpromise™承诺保证使用ab6608于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

• 功能

  Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

• 疾病相关

  Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

• 序列相似性

  Belongs to the beta-2-microglobulin family.
  Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

• 翻译后修饰

  Glycation of Ile-21 is observed in long-term hemodialysis patients.

• 细胞定位

  Secreted. Detected in serum and urine.

• Target information above from: UniProt accession P61769The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt

• 数据库链接

• Entrez Gene: 567 Human

• Omim: 109700 Human

• SwissProt: P61769 Human

• Unigene: 534255 Human

• Unigene: 702947 Human

• 别名

• B2M antibody

• B2MG_HUMAN antibody

• Beta 2 microglobin antibody

• Beta 2 microglobulin antibody

• Beta 2 microglobulin precursor antibody

• Beta chain of mhc class 1 proteins antibody

• Beta chain of MHC class I molecules antibody

• Beta-2-microglobulin form pI 5.3 antibody

• CDABP0092 antibody

• Hdcma22p antibody

• IMD43 antibody