Anti-SMC1A抗体[C2M]
参阅全部 SMC1A 一抗
小鼠单克隆抗体[C2M] to SMC1A
Mouse
适用于: ICC/IF, WBmore details
与反应: Human
Recombinant fragment corresponding to Human SMC1A aa 402-894.
Database link: Q14683
WB: HeLa cells.
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus (2) protein in vivo.
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Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.08% Sodium azide
Constituent: PBS
浓度
100 µg 浓度为 1 mg/ml
Protein A/G purified
单克隆
C2M
IgG
Abpromise™承诺保证使用ab16147于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF | Use at an assay dependent concentration. | |
| WB | (1) | Use at an assay dependent concentration. |
Entrez Gene: 8243 Human
Omim: 300040 Human
SwissProt: Q14683 Human
Unigene: 211602 Human
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