| 存储条件 |
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| Product Name | BRCA1 [D2-C6] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BRCA 1 antibody BRCA1 antibody BRCA1 DNA repair associated antibody BRCA1/BRCA2 containing complex subunit 1 antibody BRCA1/BRCA2-containing complex, subunit 1 antibody BRCA1_HUMAN antibody BRCAI antibody BRCC 1 antibody BRCC1 antibody Breast and ovarian cancer susceptibility protein 1 antibody Breast Cancer 1 antibody Breast Cancer 1 Early Onset antibody Breast cancer type 1 susceptibility protein antibody BROVCA1 antibody FANCS antibody IRIS antibody PNCA4 antibody PPP1R53 antibody Protein phosphatase 1 regulatory subunit 53 antibody PSCP antibody RING finger protein 53 antibody RNF53 antibody |
| Product description | In 1990, a breast cancer susceptibility gene, designated BRCA1, was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino terminal region, but is otherwise unrelated to any previously described proteins. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:100-1:500 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | BRCA 1 antibody BRCA1 antibody BRCA1 DNA repair associated antibody BRCA1/BRCA2 containing complex subunit 1 antibody BRCA1/BRCA2-containing complex subunit 1 antibody BRCA1_HUMAN antibody BRCAI antibody BRCC 1 antibody BRCC1 antibody Breast and ovarian cancer susceptibility protein 1 antibody Breast Cancer 1 antibody Breast Cancer 1 Early Onset antibody Breast cancer type 1 susceptibility protein antibody BROVCA1 antibody FANCS antibody IRIS antibody PNCA4 antibody PPP1R53 antibody Protein phosphatase 1 regulatory subunit 53 antibody PSCP antibody RING finger protein 53 antibody RNF53 antibody |
|---|---|
| Molecular Weight(MW) | 208 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Plasma Membrane. |
| SwissProt ID | P38398 |
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Application
Fig1: Western blot analysis of BRCA1 on human BRCA1 recombinant protein using anti-BRCA1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of BRCA1 on HEK293 (1) and BRCA1-hIgGFc transfected HEK293 (2) cell lysate using anti-BRCA1 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.
Application
Fig4:Immunohistochemical analysis of paraffin-embedded human esophagus tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.| Positive Control | Human BRCA1 recombinant protein, BRCA1-hIgGFc transfected HEK293 cell lysate, human esophagus cancer tissue, human esophagus tissue. |
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| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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