BMND1 antibody EVR1 antibody EVR4 antibody HBM antibody Low density lipoprotein receptor related protein 5 antibody Low density lipoprotein receptor related protein 7 antibody Low-density lipoprotein receptor-related protein 5 antibody LR3 antibody LRP-5 antibody Lrp5 antibody LRP5_HUMAN antibody LRP7 antibody OPPG antibody OPS antibody OPTA1 antibody Osteoporosis pseudoglioma syndrome antibody VBCH2 antibody
Product description
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth and mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). The gene which encodes LRP5 maps to human chromosome 11q13.4.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WBFC
WB:1:500-1:1,000 FC:1:100-1:200
Species Reactivity
Human
Concentration
2mg/ml
Target Information
Alternative Names
BMND1 antibody EVR1 antibody EVR4 antibody HBM antibody Low density lipoprotein receptor related protein 5 antibody Low density lipoprotein receptor related protein 7 antibody Low-density lipoprotein receptor-related protein 5 antibody LR3 antibody LRP-5 antibody Lrp5 antibody LRP5_HUMAN antibody LRP7 antibody OPPG antibody OPS antibody OPTA1 antibody Osteoporosis pseudoglioma syndrome antibody VBCH2 antibody
Fig1: Western blot analysis of LRP5 on human LRP5 recombinant protein using anti-LRP5 antibody at 1/1,000 dilution.
Application
Fig2: Flow cytometric analysis of HeLa cells with LRP5 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Positive Control
Human LRP5 recombinant protein, Hela.
Application Notes
WB:1:500-1:1,000 FC:1:100-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
