| 存储条件 |
|---|
| Product Name | CRP [E8-G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Pentraxin 1, short antibody C reactive protein antibody C reactive protein pentraxin related antibody C-reactive protein(1-205) antibody CRP antibody CRP_HUMAN antibody MGC88244 antibody Pentraxin 1 antibody PTX 1 antibody PTX1 antibody |
| Product description | C Reactive Protein(CRP) is produced by liver epithelial cells and is characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Stat3 is involved in mouse CRP gene expression. CRP bind to Fc g R and opsonize particles for phagocytosis by human polymorphonuclear leukocytes. Opsonization of zymosan by CRP is mediated through Fc g RI, while Fc g RII and Fc g RIII are receptors for SAP. Therefore, CRP and SAP play critical roles in the host defense system. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Pentraxin 1 short antibody C reactive protein antibody C reactive protein pentraxin related antibody C-reactive protein(1-205) antibody CRP antibody CRP_HUMAN antibody MGC88244 antibody Pentraxin 1 antibody PTX 1 antibody PTX1 antibody |
|---|---|
| Molecular Weight(MW) | 25 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P02741 |
|---|
Application
Fig1: Western blot analysis of CRP on human CRP recombinant protein using anti-CRP antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-CRP antibody. Counter stained with hematoxylin.
Application
Fig3: Flow cytometric analysis of MCF-7 cells with CRP antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human CRP recombinant protein, human liver cancer tissue, MCF-7. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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