| 存储条件 |
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| Product Name | NKX3A [C3-H4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BAPX 2 antibody BAPX2 antibody Homeobox protein NK-3 homolog A antibody Homeobox protein Nkx 3.1 antibody Homeobox protein Nkx-3.1 antibody Homeobox protein Nkx3.1 antibody NK homeobox (Drosophila) family 3 A antibody NK homeobox family 3 A antibody NK homeobox, family 3, member A antibody NK3 homeobox 1 antibody NK3 transcription factor homolog A antibody NK3 transcription factor related locus 1 antibody NKX 3 antibody Nkx 3.1 antibody NKX 3A antibody NKX3 1 antibody NKX3 antibody Nkx3-1 antibody NKX3.1 antibody Nkx3.1, mouse, homolog of antibody NKX31_HUMAN antibody NKX3A antibody |
| Product description | The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:250~1:1000 IHC:1:20~1:100 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | BAPX 2 antibody BAPX2 antibody Homeobox protein NK-3 homolog A antibody Homeobox protein Nkx 3.1 antibody Homeobox protein Nkx-3.1 antibody Homeobox protein Nkx3.1 antibody NK homeobox (Drosophila) family 3 A antibody NK homeobox family 3 A antibody NK homeobox family 3 member A antibody NK3 homeobox 1 antibody NK3 transcription factor homolog A antibody NK3 transcription factor related locus 1 antibody NKX 3 antibody Nkx 3.1 antibody NKX 3A antibody NKX3 1 antibody NKX3 antibody Nkx3-1 antibody NKX3.1 antibody Nkx3.1 mouse homolog of antibody NKX31_HUMAN antibody NKX3A antibody |
|---|---|
| Molecular Weight(MW) | 26 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | Q99801 |
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Application
Fig1: Western blot analysis of NKX3A on LNCaP cell lysate using anti-NKX3A antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-NKX3A antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of PC-3 cells with NKX3A antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).| Positive Control | LNCaP cell lysate, human liver tissue, human prostate tissue, PC-3. |
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| Application Notes | WB:1:250~1:1000 IHC:1:20~1:100 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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