C3IP1 antibody CUL3 interacting protein 1 antibody CUL3-interacting protein 1 antibody DKIR antibody DKIR homolog antibody FLJ27152 antibody hDKIR antibody Kelch like 12 (Drosophila) antibody Kelch like 12 antibody Kelch like 12 variant antibody Kelch like protein 12 antibody Kelch like protein C3IP1 antibody kelch-like family member 12 antibody Kelch-like protein 12 antibody KLH12_HUMAN antibody KLHL 12 antibody klhl12 antibody OTTHUMP00000038799 antibody
Product description
KLHL12 (kelch-like protein 12), also known as C3IP1 (CUL3-interacting protein 1), DKIR or FLJ27152, is a 568 amino acid protein that is a component of an ubiquitin-protein E3 ligase complex, which includes at least CUL-3. KLHL12 is a substrate-specific adapter for the complex, which negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of Dvl-3. KLHL12 contains six Kelch repeats and one BTB (POZ) domain, which is required for interaction with CUL-3. KLHL12 has highest expression in testis, with lower levels found in the submandibular salivary gland. The gene that encodes KLHL12 maps to human chromosome 1q32.1.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WB
WB:1:500-1:1,000
Species Reactivity
Human
Concentration
2mg/ml
Purification
Unpurified
Target Information
Alternative Names
C3IP1 antibody CUL3 interacting protein 1 antibody CUL3-interacting protein 1 antibody DKIR antibody DKIR homolog antibody FLJ27152 antibody hDKIR antibody Kelch like 12 (Drosophila) antibody Kelch like 12 antibody Kelch like 12 variant antibody Kelch like protein 12 antibody Kelch like protein C3IP1 antibody kelch-like family member 12 antibody Kelch-like protein 12 antibody KLH12_HUMAN antibody KLHL 12 antibody klhl12 antibody OTTHUMP00000038799 antibody
