| 存储条件 |
|---|
| Product Name | DKK3 [C6-A5] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Dickkopf 3 antibody Dickkopf 3 homolog (Xenopus laevis) antibody Dickkopf 3 homolog antibody Dickkopf homolog 3 antibody Dickkopf related protein 3 antibody Dickkopf related protein 3 Precursor antibody Dickkopf WNT signaling pathway inhibitor 3 antibody Dickkopf, Xenopus, homolog of, 3 antibody Dickkopf-3 antibody Dickkopf-related protein 3 antibody Dickkopf3 antibody DKK 3 antibody Dkk-3 antibody DKK3 antibody DKK3_HUMAN antibody hDkk 3 antibody hDkk-3 antibody hDkk3 antibody Regulated in glioma antibody REIC antibody RIG antibody RIG-like 5-6 antibody RIG-like 7-1 antibody |
| Product description | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:250~1:1000 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | Dickkopf 3 antibody Dickkopf 3 homolog (Xenopus laevis) antibody Dickkopf 3 homolog antibody Dickkopf homolog 3 antibody Dickkopf related protein 3 antibody Dickkopf related protein 3 Precursor antibody Dickkopf WNT signaling pathway inhibitor 3 antibody Dickkopf Xenopus homolog of 3 antibody Dickkopf-3 antibody Dickkopf-related protein 3 antibody Dickkopf3 antibody DKK 3 antibody Dkk-3 antibody DKK3 antibody DKK3_HUMAN antibody hDkk 3 antibody hDkk-3 antibody hDkk3 antibody Regulated in glioma antibody REIC antibody RIG antibody RIG-like 5-6 antibody RIG-like 7-1 antibody |
|---|---|
| Molecular Weight(MW) | 38 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | Q9UBP4 |
|---|
Application
Fig1: Western blot analysis of DKK3 on human DKK3 recombinant protein using anti-DKK3 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of DKK3 on HEK293 (1) and DKK3-hIgGFc transfected HEK293 (2) cell lysate using anti-DKK3 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-DKK3 antibody. Counter stained with hematoxylin.| Positive Control | Human DKK3 recombinant protein, DKK3-hIgGFc transfected HEK293 cell lysate, human brain tissue. |
|---|---|
| Application Notes | WB:1:250~1:1000 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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